GRK在恶性肿瘤病理中的作用

G protein coupled receptors (GPCRs) are a superfamily of membrane receptors. G protein-coupled receptor kinases (GRKs) constitute a family of seven serine/threonine protein kinases that specifically recognize and phosphorylate agonist-activated GPCRs, thereby terminating the GPCR-mediated the signal transduction pathway. Newly researches found that in a variety of malignant tumors , GRKs play an important role in angiogenesis, proliferation, migration and invasion of tumor cells by regulating GPCRs signals and other signaling pathways. In this article, the role of GRKs in development of malignant tumor is reviewed in this paper.