去泛素化酶UCH-L1 在恶性胶质瘤侵袭中的作用

im: To investigate the effects of UCH-L1 on invasion of glioma cells under hypoxia, and to explore the molecular mechanisms involved. Methods: Cell biology, molecular biology, and pharmacology approaches and methods were used in this study. Under hypoxia condition, UCH-L1 affect the invasion, cell proliferation, cell viability. Results: Under hypoxia condition, the ability of the migration, invasion, proliferation, viability of human glioma cells were decreased after silencing of UCH-L1 expression in human glioma cells U251 and T98G. The level of cleaved caspase 3 and cleaved PARP were significantly increased after silencing of UCH-L1 expression. Conclusion: Contributes to inhibition of apoptosis, UCH-L1 promotes the invasion, migration, survival and proliferation of glioma cells under hypoxia.???