活血养血汤对兔脊髓缺血再灌注损伤Bcl-2和Bax表达的影响

Objective: To detect the expression of B cell lymphoma/lewkmia-2(Bcl-2)、Bcl-2 associated X protein(Bax) during Spinal Cord Ischemia-reperfusion injury via HuoXue YangXue Decoction in order for its involved mechanism. Methods: Ninety New Zealand rabbits were randomly divided into there groups: sham-operated, operated and HuoXue YangXue Decoction groups (n=30). They were given either saline、saline and HuoXue YangXue Decoction one week before opereation,Lumbar arter were seperated only in the sham operation group,Othere there groups were performed into models of spinal cord ischemia-referfusion injury. The expression of Bcl-2、Bax were observed at hour 0.5h, 1h, 4h, 8h, 12h following perfusion. Results: (1)In sham operation group the expression of Bcl-2、Bax,were lowest；(2)Compared with sham operation group, the expression of Bcl-2、Bax in the other two group were obviously increased at different time (P<0.05 or P<0.01) (3) Compared with model group, the expression of Bcl-2 in Huoxue Tongdu Decoction group were significantly increase (P<0.05 or P<0.01);Compared with model group, the expression of Bax in Huoxue Tongdu Decoction group were significantly reduce (P<0.05 or P<0.01).