IGF2BP2基因多态性与中国北方汉族人群精神分裂症发病的遗传学关联研究

Objective To elucidate the genetic association between the IGF2BP2 gene polymorphisms and schizophrenia in a Chinese Han population in the north of China. Methods Genomic DNA was isolated from the whole blood samples. A single nucleotide polymorphism, rs4402960 (Dra I site) present in the IGF2BP2 gene, was detected using PCR-based restriction fragment length polymorphism analysis among 790 patients with schizophrenia and 1083 ethnicity-matched healthy controls. The Hardy-Weinberg equilibrium for genotypic distribution of rs4402960 was estimated by the goodness-of-fit χ2 test, allelic and genotypic association of the IGF2BP2 gene with the disease and the relationship between allelic frequencies and the clinical phenotypes of schizophrenia were statistically computed. Results The goodness- of-fit χ2 test showed that the genotypic distributions of rs4402960 did not deviate from Hardy-Weinberg equilibrium in both the patient group and the control group（P＞0.05）. The χ2 test showed allelic associations for rs4402960（χ2=7.056，P=0.008，OR=1.221，95%CI 1.013-1.476); the frequencies of genotypes with rs4402960 T allele were significantly higher in the patient group than in the control group (χ2=4.972，P=0.026). The gender differences in rs4402960 association were observed and the IGF2BP2 gene was more likely to be associated with male patients (χ2=8.102，P=0.004 for allelic association；χ2=8.392，P=0.015 for genotypic association) than female patients (P＞0.05). There were no correlations between allelic or genotypic frequencies and the clinical phenotypes of schizophrenia（P＞0.05）. Conclusion The IGF2BP2 locus may be associated with schizophrenia in the Chinese population.