纺锤体组装检验点:染色体稳定性的守护神
Spindle Assembly Checkpoint: Guardian of Chromosome Stability
有丝分裂是真核生物进行细胞增殖的基本方式，其根本目的是准确无误地将复制好的染色体平均分配到两个子细胞中。在细胞有丝分裂过程中，纺锤体组装检验点的作用是产生"等待"信号直至所有的染色体都排列到赤道板上并建立正确的双极定向，以确保染色体的均等分配。在高等动物中，细胞的纺锤体组装检验点功能行使异常，染色体分离将出现错误，导致子代细胞的染色体数量不稳定性，进而诱发肿瘤或导致其它疾病的发生。纺锤体组装检验点一直以来都是细胞生物学家研究的热点，然而其作用的分子基础和调控因素还不是十分明了，本文将对近年关于纺锤体检验点的研究进展进行总结探讨。
he eukaryotic life stems from cell division by which parental genome is segregated into two daughter cells. To achieve the equal distribution, protein machinery named spindle assembly checkpoint (SAC) ensures all chromosomes are bi-oriented and accurate attached to spindle microtubule prior to anaphase onset. Perturbation of SAC assembly dynamics and functional plasticity contributes to chromosome instability and aneuploidy underlying tumorigenesis. This essay highlights recent progresses toward a better understanding of SAC. We also discuss the perspectives of future research on this exciting avenue.
朱丽娟、窦震、王志凯、姚雪彪
细胞生物学分子生物学遗传学
有丝分裂动点纺锤体组装检验点染色体不稳定性肿瘤
mitosiskinetochorespindle assembly checkpointchromosome instabilitytumor
朱丽娟,窦震,王志凯,姚雪彪.纺锤体组装检验点:染色体稳定性的守护神[EB/OL].(2014-04-11)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/201404-153.点此复制
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