三草降压汤有效组分对自发性高血压大鼠血浆血管活性舒缩因子的影响
Influences on the diastolic-systolic factors of vasculars in SHR serum of the components of Sancao Jiangya Decoction
目的：观察三草降压汤有效组分的降压作用与血管舒缩因子ET-1、NO、ANGII的之间的关系。方法：采用酶联免疫吸附法（ELISA）检测SCD有效组分干预后SHR大鼠血浆中AngⅡ和ET-1的浓度；用硝酸还原酶法检测其NO的含量，以此探讨SCD有效组分的降压作用机理。结果：SCD有效组分显著升高血浆NO浓度，降低ET-1浓度，与阳性对照硝苯地平无显著差异。但其对ANG-II无明显影响SCD有效组分可以通过升高血管舒张因子NO，降低血管收缩因子ET-1，发挥其降压作用。
IObjective: to observe the three grass decompression soup effective component of the hypotensive effect and vasomotor factor ET - 1, NO, ANGII relationship between. Methods: ELISA method (ELISA) test SCD effective components after intervention SHR rats plasma Ang Ⅱ and ET 1 concentration; With nitric acid reduction method of testing the NO content, so as to discuss the effective component of SCD antihypertensive mechanism. Results: the effective constituents in SCD plasma NO significant rise, and to decrease the concentration of ET 1 concentration, and the positive control nifedipine NO significant difference. But its ANG - II not significantly affect the SCD effective component can be increased through vasodilation factor NO, reduce vascular contraction factor ET - 1, play the decompression effect.
赵伟鹏、王冬、王雪茜、王庆国
医药卫生理论中医学基础医学
中药实验药理学三草降压汤有效组分自发性高血压大鼠，血管舒缩因子
raditional Chinese Medicine Experimental Pharmacologycomponents of Sancao Jiangya DecoctionSHRdiastolic-systolic factors of vasculars
赵伟鹏,王冬,王雪茜,王庆国.三草降压汤有效组分对自发性高血压大鼠血浆血管活性舒缩因子的影响[EB/OL].(2013-03-14)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/201303-565.点此复制
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