基于PPI网络搜寻结直肠癌中枢基因

【Objective】This paper aims to search for central genes of colorectal cancer based on PPI networks through bioinformatics methods.【Methods】To search for the central genes of colorectal cancer, this paper analyzed three gene chip datasets from the Gene Expression Omnibus (GEO) database (GSE21815, GSE21510, GSE113513). Firstly, the differentially expressed genes obtained by Venn analysis were subjected to functional enrichment and pathway analysis to understand the reason for clustering. Then, the protein interaction network of differentially expressed genes was constructed by STRING database, and sub-network module analysis was carried out to more accurately explore the core path of colorectal cancer. Finally, the hub genes were screened based on the degree of binding during colorectal carcinogenesis.【Results】This paper found the top ten genes with higher binding scores in the entire protein interaction network. These ten genes were identified as hub genes that play a key role in the development of colorectal cancer, and these genes are closely related to the cell cycle process. The discovered hub genes can be a therapeutic target for colorectal cancer..