乙肝病毒特性与致病机理研究进展

Hepatitis B virus (HBV) has been recognized as a major etiologic agent of chronic viral hepatitis in china. More than half of the patients with HBV infection develop chronic liver diseases including chronic hepatitis (CH), live cirrhosis (LC) and hepatocellular carcinoma (HCC). Recently, several reports have indicated that activated T cell response may play a role in chronicity and hepatocellular injury in HBV or HCV infection. It has been currently disclosed that CD4+ T cells, which are involved in antiviral response, are subdivided into two populations based on cytokine secretion profiles, so called Th1 and Th2 type cells. Th1 type cells regulate the cellular immune response followed by producing cytokines such as interleukin-2(IL-2),interferon- Y (IFN-Y), while Th2 type cells regulate the humoral immune response, followed by producing cytokines such as interleukin-4(IL-4) and interleukin-10(IL-10).Some studies have shown that these Th1/Th2 type cytokines create the complex network and are involved in pathophysiology of infectious diseases such as human immunodeficiency virus infection, leprosy and some parasitosis.