Precise transcriptional control of cellular quiescence by BRAVO/WOX5 complex in Arabidopsis roots
Precise transcriptional control of cellular quiescence by BRAVO/WOX5 complex in Arabidopsis roots
SUMMARY Root growth and development are essential features for plant survival and the preservation of terrestrial ecosystems. In the Arabidopsis primary root apex, stem-cell specific transcription factors BRAVO and WOX5 co-localize at the Quiescent Center (QC) cells, where they repress cell division so that these cells can act as a reservoir to replenish surrounding stem cells, yet their molecular connection remains unknown. Here, by using empirical evidence and mathematical modeling, we establish the precise regulatory and molecular interactions between BRAVO and WOX5. We found that BRAVO and WOX5 regulate each other besides forming a transcription factor complex in the QC necessary to preserve overall root growth and architecture. Our results unveil the importance of transcriptional regulatory circuits at the quiescent and stem cells to the control of organ initiation and growth of plant tissues.
Burkart Rebecca Corinna、Iba?es Marta、Beteg¨?n-Putze Isabel、Bosch Nadja、Frigola David、Mart¨anez Cristina、Prat Salom¨|、Marqu¨¨s-Bueno Mar、Planas-Riverola Ainoa、Stahl Yvonne、Ca?o-Delgado Ana I.、Mercadal Josep、Vilarrasa-Blasi Josep
Institute for Developmental Genetics, Heinrich-Heine University, Universit?tsstra?e 1Departament de Mat¨¨ria Condensada, Facultat de F¨asica, Universitat de Barcelona||Universitat de Barcelona Institute of Complex Systems (UBICS)Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB (Cerdanyola del Vall¨¨s)Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB (Cerdanyola del Vall¨¨s)Departament de Mat¨¨ria Condensada, Facultat de F¨asica, Universitat de BarcelonaDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnolog¨aa (CNB)Department of Plant Molecular Genetics, Centro Nacional de Biotecnolog¨aa (CNB)Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB (Cerdanyola del Vall¨¨s)Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB (Cerdanyola del Vall¨¨s)Institute for Developmental Genetics, Heinrich-Heine University, Universit?tsstra?e 1Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB (Cerdanyola del Vall¨¨s)Departament de Mat¨¨ria Condensada, Facultat de F¨asica, Universitat de Barcelona||Universitat de Barcelona Institute of Complex Systems (UBICS)Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB (Cerdanyola del Vall¨¨s)||Department of Biology, Stanford University
植物学细胞生物学分子生物学
Root growthBrassinosteroidsBRAVOWOX5root growthstem cellquiescent centremathematical modeling
Burkart Rebecca Corinna,Iba?es Marta,Beteg¨?n-Putze Isabel,Bosch Nadja,Frigola David,Mart¨anez Cristina,Prat Salom¨|,Marqu¨¨s-Bueno Mar,Planas-Riverola Ainoa,Stahl Yvonne,Ca?o-Delgado Ana I.,Mercadal Josep,Vilarrasa-Blasi Josep.Precise transcriptional control of cellular quiescence by BRAVO/WOX5 complex in Arabidopsis roots[EB/OL].(2025-03-28)[2025-06-19].https://www.biorxiv.org/content/10.1101/2020.07.15.203638.点此复制
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