rkB受体再循环的研究进展

he endocytic pathway tightly controls the activity of tyrosine kinase receptor B (TrkB). Ligand-induced endocytosis can drive receptors into divergent lysosomal and recycling pathways, producing essentially opposite effects on the strength and duration of cellular signaling. This article reviews recent findings that the molecular machinery and functional implications of receptor sorting in the endocytic pathway, in addition to promoting two kinds of recycling.