朊蛋白在阿尔兹海默症中作用的研究进展
dvances in functions of cellular prion protein in Alzheimer's Disease
蛋白质构象病是一类由于蛋白构象错误而引发组织病变的疾病。阿尔兹海默症是一类典型的蛋白质构象病，而关于其相关蛋白，β淀粉样多肽（Aβ）诱发疾病的机理目前有很多种说法，最近发现朊蛋白在Aβ诱发阿尔兹海默症的过程中有着较为重要的作用。本文综述了朊蛋白与Aβ的主要作用方式以及这些相互作用与阿尔兹海默症关系研究的最新研究进展。
lzheimer's Disease is a typical protein conformation disorder disease which is caused by misfolded and toxic cellular proteins. There are many mechanisms about the pathogenesis of β-amyloid(Aβ). Recently the cellular prion protein is found to be related to the Aβ-induced toxicity. This review mainly focus on the recent advances about the interactions between Aβ and cellular prion protein.
李秋野、陈永湘、李艳梅
神经病学、精神病学基础医学分子生物学
生物化学阿尔兹海默症β淀粉样多肽朊蛋白
biochemistryAlzheimer's Diseaseβ-amyloidcellular prion protein
李秋野,陈永湘,李艳梅.朊蛋白在阿尔兹海默症中作用的研究进展[EB/OL].(2012-05-29)[2025-08-16].http://www.paper.edu.cn/releasepaper/content/201205-456.点此复制
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