Preparation of <sup>188</sup>Re-HEDP lyophilized kit for instant bone metastases therapy
ZHANG Yan ZHU Hua LI Nan YANG Zhi MA Yun-Xia
Preparation of <sup>188</sup>Re-HEDP lyophilized kit for instant bone metastases therapy
Preparation of <sup>188</sup>Re-HEDP lyophilized kit for instant bone metastases therapy
摘要
Hydroxyethylidene diphosphonate (HEDP) was prepared and labeled with rhenium-188. Its lyophilized kit was developed for instant preparing of 188Re-HEDP. 188Re-HEDP showed high focile uptake in normal mice (>30% ID/g at carrier co-injection) in BABLC/SPF mice. High quality single photon emission computed tomography (SPECT) image of New Zealand rabbit was obtained at 4 h after intravenous injection of 74 MBq radiotracer. The lyophilized HEDP kit affords the new opportunity for routine clinical application in bone metastases therapy.
评论