中心性血管化珊瑚石人工骨的体内实验研究

In tObjective:To research the blood supply and vessel regeneration of the centricity vascularized coralline. Methods：Nine New Zealand Rabbits' were selected for the experiment. Each side of the hind legs were randomly divided into experimental group and control group. On the experimental group, femoral artery was inserted into the central tunnel of the coralline. The vascularied coralline then implanted into the femur. The non-vascularized coralline as control was implanted into the other femur. The animals were euthanized at 2nd,4th and 8th week post -operation. The histology，X-ray and angiography of the implants were investigated. Results ：The centricity vascularized coralline were filled with new -generate vessels at 8th week in the experimental group and only a few new-born vessels in control group. Conclusion: Centricity vascularized coralline as a method to improve the blood supply and osteogenesis is feasible and effective, it can become the new way for the clinical application of coralline.