亚硒酸钠对小鼠体内汞免疫毒性的解毒作用研究

In the present study, we explored the effects of Na2SeO3 on Hg-induced immunotoxicity. Balb/c mice were sole- and co-exposed to mercury (including HgCl2 and MeHg) and/or Na2SeO3 contaminated drinking water, and the influences of exposure concentration (0.001, 0.01, and 0.1 mM as Hg) and Se/Hg molar ratios (0:1, 1/3:1, 1:1 and 3:1) were further explored. The effects of Hg or Se on the immune system of Balb/c mice were investigated by determining the proliferation of T and B lymphocytes and the activity of natural killer cells. After 14 days' exposure via drinking water, Hg exposure alone induced a dose-dependent suppression effect, whereas Se provided promotion effects at low exposure level (0.01 mM) and inhibition effects at high exposure level (0.03 mM). Under Hg and Se coexposure condition, the effects on immunotoxicity depended on the Hg species, Se/Hg ratio, and exposure concentration. Specifically, at low Hg concentration (0.001 mM), greater Se ingestion exhibited stronger protective effects on Hg-induced suppression effect mainly by way of decreasing Hg concentrations in target organs. At greater Hg concentration (0.01 and 0.1 mM), immunotoxicity induced by Se became evident, and the protective effects appeared more significant at an Se/Hg molar ratio of 1:1. Our results suggested that both Se/Hg molar ratio and concentration could affect the antagonistic effects between Se and Hg, therefore should be considered in future mechanism studies.