Epidemiological and immunological features of obesity and SARS-CoV-2
Epidemiological and immunological features of obesity and SARS-CoV-2
Abstract Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response are poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and, remarkably homogenous immune activity across BMI categories suggests natural- and vaccine-induced protection may be similar across these groups.
Kucharski Adam J、Barouch Dan H、de Saint Aubin Michael、Menon Anil S、Lauffenburger Douglas A、Julg Boris D、Nilles Eric J、Siddiqui Sameed M、Fischinger Stephanie、Bartsch Yannic C、Mormann Benjamin、Gebre Makda、Burke John、Jambaulikar Guruprasad、Boyer Edward、Hasdianda Mohammad A、Gorman Matthew J、Musk Elon R、Slein Matthew、Loesche Michael、Atyeo Caroline、Gluck Matthew J、Zhou Guohai、Chen Zhilin、Rhee Justin、Zhu Alex Lee、Sabeti Pardis、Petersen Eric、Yu Jingyou、Alter Galit、Berger Samuel
London School of Hygiene and Tropical MedicineBroad Institute of MIT and Harvard||Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolHarvard Humanitarian InitiativeSpace Exploration Technologies CorpDepartment of Biological Engineering, Massachusetts Institute of TechnologyBroad Institute of MIT and HarvardBrigham and Women?ˉs Hospital||Harvard Medical School||Harvard Humanitarian Initiative||Massachusetts Consortium on Pathogen ReadinessComputational and Systems Biology Program, Massachusetts Institute of Technology||Broad Institute of MIT and HarvardRagon Institute of MGH, MIT and HarvardRagon Institute of MGH, MIT and HarvardBrigham and Women?ˉs Hospital||Space Exploration Technologies CorpRagon Institute of MGH, MIT and Harvard||Harvard T.H. Chan School of Public HealthRagon Institute of MGH, MIT and HarvardBrigham and Women?ˉs Hospital||Harvard Medical SchoolBrigham and Women?ˉs Hospital||Harvard Medical SchoolBrigham and Women?ˉs Hospital||Harvard Medical SchoolRagon Institute of MGH, MIT and HarvardSpace Exploration Technologies CorpRagon Institute of MGH, MIT and HarvardBrigham and Women?ˉs Hospital||Space Exploration Technologies CorpRagon Institute of MGH, MIT and HarvardSpace Exploration Technologies Corp||Icahn School of Medicine- Mount SinaiBrigham and Women?ˉs Hospital||Harvard Medical SchoolRagon Institute of MGH, MIT and HarvardSpace Exploration Technologies CorpRagon Institute of MGH, MIT and HarvardMassachusetts Consortium on Pathogen Readiness||Broad Institute of MIT and Harvard||Harvard T.H. Chan School of Public Health||Howard Hughes Medical InstituteSpace Exploration Technologies CorpRagon Institute of MGH, MIT and Harvard||Harvard T.H. Chan School of Public HealthMassachusetts Consortium on Pathogen Readiness||Broad Institute of MIT and HarvardSpace Exploration Technologies Corp
医药卫生理论医学研究方法基础医学
SARS-CoV-2COVID-19obesityepidemiologyimmunity
Kucharski Adam J,Barouch Dan H,de Saint Aubin Michael,Menon Anil S,Lauffenburger Douglas A,Julg Boris D,Nilles Eric J,Siddiqui Sameed M,Fischinger Stephanie,Bartsch Yannic C,Mormann Benjamin,Gebre Makda,Burke John,Jambaulikar Guruprasad,Boyer Edward,Hasdianda Mohammad A,Gorman Matthew J,Musk Elon R,Slein Matthew,Loesche Michael,Atyeo Caroline,Gluck Matthew J,Zhou Guohai,Chen Zhilin,Rhee Justin,Zhu Alex Lee,Sabeti Pardis,Petersen Eric,Yu Jingyou,Alter Galit,Berger Samuel.Epidemiological and immunological features of obesity and SARS-CoV-2[EB/OL].(2025-03-28)[2025-06-03].https://www.medrxiv.org/content/10.1101/2020.11.11.20229724.点此复制
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