Neutralization potential of Covishield vaccinated individuals against B.1.617.1
Neutralization potential of Covishield vaccinated individuals against B.1.617.1
Abstract Covishield comprises the larger proportion in the vaccination program in India. Hence, it is of utmost importance to understand neutralizing capability of vaccine against the B.1.617.1 variant which is considered to responsible for surge of the cases in India. The neutralizing-antibody (NAb) titer against B.1.167.1 and prototype B.1 variant (D614G) was determined of the vaccine sera (4 weeks after second dose) of COVID-19 na?ve subjects (n=43) and COVID-19 recovered subjects (n=18). The results demonstrated that sera of COVID-19 recovered subjects (n=18) who received two doses of Covishield have higher NAb response compared to the COVID-19 naive with a significant difference (p<0.0001) in NAb titer against B.1 and B.1.617.1 In-spite of reduction in the neutralizing titer against B.1.617.1 variant; Covishield vaccine-induced antibodies are likely to be protective to limit the severity and mortality of the disease in the vaccinated individuals.
Gupta Nivedita、Sahay Rima R.、Kumar Sanjay、Abraham Priya、Panda Samiran、Sapkal Gajanan N.、Patil Deepak Y.、Shete Anita M.、Deshpande Gururaj、Nyayanit Dimpal A、Bhargava Balram、Yadav Pragya D.
Indian Council of Medical Research, V Ramalingaswami BhawanIndian Council of Medical Research-National Institute of VirologyDepartment of Neurosurgery, Command Hospital (Southern Command), Armed Forces Medical College (AFMC)Indian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research, V Ramalingaswami BhawanIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research, V Ramalingaswami BhawanIndian Council of Medical Research-National Institute of Virology
医学研究方法预防医学基础医学
Variant under investigationB.1.617neutralizationCovishieldSARS-CoV-2
Gupta Nivedita,Sahay Rima R.,Kumar Sanjay,Abraham Priya,Panda Samiran,Sapkal Gajanan N.,Patil Deepak Y.,Shete Anita M.,Deshpande Gururaj,Nyayanit Dimpal A,Bhargava Balram,Yadav Pragya D..Neutralization potential of Covishield vaccinated individuals against B.1.617.1[EB/OL].(2025-03-28)[2025-04-27].https://www.biorxiv.org/content/10.1101/2021.05.12.443645.点此复制
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