一些黄酮及其衍生物的氧钒配合物之合成及生物活性

Vanadium compounds have a wide spectrum of biological activities, e.g. antidiabetic, anticancer, spermicidal, and anti-inflammatory; amongst, the anti-diabetic activity is the most attractive, making vanadium complexes good candidates for developing therapeutic agents for diabetes. To overcome the potential metal toxicity, researchers put great efforts in improve the antioxidant activities of ligands as well as complexes. Considering flavonoids are excellent natural antioxidants and ligands, we synthesized a series of vanadyl-flavonoid compounexes and evaluated their antioxidant capacity and hypoglycemic effects. The result showed that quercetin and the derivative quercetin 5'-sulfonate, myricetin, kaempferol formed coordination compounds by the carbonyl and 3-hydroxyl groups while naringenin and hesperetin did not. The vanadyl-flavonoid complexes exhibit much better antioxidant capacity than vanadyl maltolato and derivatives. Vanayl complexes with quercetin, myricetin, kaempferol showed good hypoglycemic effects while bis(quercetin 5'-sulfonate)oxovanadium did not although it exhibited much better solubility than the parental compouns. The present work provide new insights to the structure-activity relationship of antidiabetic vanadium compounds.