In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility
In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility
Abstract Brain markers of oxidative damage increase with advancing age. In response, brain antioxidant levels may also increase with age, although this has not been well investigated. Here we used edited magnetic resonance spectroscopy to quantify endogenous levels of glutathione (GSH, one of the most abundant brain antioxidants) in 37 young (mean: 21.8 (2.5) years; 19 F) and 23 older adults (mean: 72.8 (8.9) years; 19 F). Accounting for age-related atrophy, we identified higher frontal and sensorimotor GSH levels for the older compared to the younger adults. For the older adults only, higher sensorimotor (but not frontal) GSH was correlated with poorer balance, gait, and manual dexterity. This suggests a regionally-specific relationship between higher brain oxidative stress levels and motor performance declines with age. We suggest these findings reflect a compensatory upregulation of GSH in response to increasing brain oxidative stress with normal aging. Together, these results provide insight into age differences in brain antioxidant levels and implications for motor function.
Edden R. A. E.、Porges E. C.、Hass C. J.、Hupfeld K. E.、Hyatt H. W.、Mikkelsen M.、Seidler R. D.、Jerez P. Alvarez
Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine||F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger InstituteDepartment of Clinical and Health Psychology, University of FloridaDepartment of Applied Physiology and Kinesiology, University of FloridaDepartment of Applied Physiology and Kinesiology, University of FloridaDepartment of Applied Physiology and Kinesiology, University of FloridaRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine||F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger InstituteDepartment of Applied Physiology and Kinesiology, University of Florida||Department of Neurology, University of FloridaDepartment of Applied Physiology and Kinesiology, University of Florida
基础医学神经病学、精神病学生物化学
glutathione (GSH)magnetic resonance spectroscopy (MRS)Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy (HERMES)agingbalancegaitmanual dexterity
Edden R. A. E.,Porges E. C.,Hass C. J.,Hupfeld K. E.,Hyatt H. W.,Mikkelsen M.,Seidler R. D.,Jerez P. Alvarez.In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility[EB/OL].(2025-03-28)[2025-05-14].https://www.biorxiv.org/content/10.1101/2020.10.14.339507.点此复制
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