胃肠道肿瘤的多光子成像与光学活检

he assessment of tumor invasive depth, metastasis and if surgical margin had residual cancer were in urgent need of an in situ, real-time diagnosis technology to determine surgical treatment of gastrointestinal tract malignant tumor and theextent of resection surgery. Multiphoton microscopy can provide gastrointestinal tissue structure and cell morphology of real-time information. Multiphoton imaging technology had no exogenous marker of tissue, was extremely sensitive to collagen, had light of the tissue damage and deep penetration depth. Such characters enable the technology to be applied ingastrointestinal tumor as a new optical biopsy. The review aimed to overview the feasibility of multiphoton imaging forevaluation of gastrointestinal tumor optical biopsy and had a discussion on the development prospect of multiphoton imaging technology considerable.