Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study
Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study
Abstract Autism Spectrum Disorders (ASD) are a set of neurodevelopmental conditions characterised by difficulties in social interaction and communication as well as stereotyped and restricted patterns of interest. Autistic traits exist in a continuum across the general population, whilst the extreme end of this distribution is diagnosed as clinical ASD. While many studies have investigated brain structure in autism using a case-control design, few have used a dimensional approach. To add to this growing body of literature, we investigated the structural brain correlates of autistic traits in a mixed sample of adults (N=91) with and without a clinical diagnosis of autism. We examined regional brain volumes (using voxel-based morphometry and surface-based morphometry) and white matter microstructure properties (using Diffusion Tensor Imaging). Our findings show widespread grey matter differences, including in the social brain regions, and some evidence for white matter microstructure differences related to higher autistic traits. These grey matter and white matter microstructure findings from our study are consistent with previous reports and support the brain structural differences in ASD. These findings provide further support for shared aetiology for autistic traits across the diagnostic divide.
Neufeld Janina、O?ˉConnell Garret、DeLuca Vincent、Haffey Anthony、Chandran Varun Arunachalam、Chakrabarti Bhismadev、Pliatsikas Christos
Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women?ˉs and Children?ˉs Health, Karolinska Institutet & Stockholm Health Care ServicesSchool of Mind and Brain, Humboldt UniversityDepartment of Language and Culture, UiT- The Arctic University of NorwayCentre for Autism, School of Psychology and Clinical Language Sciences (SPCLS), University of ReadingCentre for Autism, School of Psychology and Clinical Language Sciences (SPCLS), University of ReadingCentre for Autism, School of Psychology and Clinical Language Sciences (SPCLS), University of Reading||Department of Psychology, Ashoka University||India Autism CenterSchool of Psychology and Clinical Language Sciences, University of Reading, Harry Pitt Building||Centro de Ciencia Cognitiva, Facultad de Lenguas y Educaci¨?n, Universidad Antonio de Nebrija
神经病学、精神病学基础医学生物科学研究方法、生物科学研究技术
Autism spectrum disordersautistic traitsgrey matterwhite matter microstructureStructural MRIDiffusion Tensor Imaging
Neufeld Janina,O?ˉConnell Garret,DeLuca Vincent,Haffey Anthony,Chandran Varun Arunachalam,Chakrabarti Bhismadev,Pliatsikas Christos.Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study[EB/OL].(2025-03-28)[2025-04-30].https://www.biorxiv.org/content/10.1101/2021.05.29.446259.点此复制
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