Harmonized-Multinational qEEG Norms (HarMNqEEG)
Harmonized-Multinational qEEG Norms (HarMNqEEG)
Abstract This paper extends our frequency domain quantitative electroencephalography (qEEG) methods pursuing higher sensitivity to detect Brain Developmental Disorders. Prior qEEG work lacked integration of cross-spectral information omitting important functional connectivity descriptors. Lack of geographical diversity precluded accounting for site-specific variance, increasing qEEG nuisance variance. We ameliorate these weaknesses. i) Create lifespan Hermitian Riemannian multinational qEEG norms for cross-spectral tensors. These norms result from the HarMNqEEG project fostered by the Global Brain Consortium. We calculate the norms with data from 9 countries, 12 devices, and 14 studies, including 1564 subjects. Instead of raw data, only anonymized metadata and EEG cross-spectral tensors were shared. After visual and automatic quality control developmental equations for the mean and standard deviation of qEEG traditional and Hermitian Riemannian descriptive parameters were calculated using additive mixed-effects models. We demonstrate qEEG “batch effects” and provide methods to calculate harmonized z-scores. ii) We also show that the multinational harmonized Hermitian Riemannian norms produce z-scores with increased diagnostic accuracy to predict brain dysfunction at school-age produced by malnutrition only in the first year of life. We provide data and software for constructing norms. iii) We offer open code and data to calculate different individual z-scores from the HarMNqEEG dataset. These results contribute to developing bias-free, low-cost neuroimaging technologies applicable in various health settings. HighlightsWe create lifespan Hermitian Riemannian qEEG norms for cross-spectral tensors.The norms are based on 9 countries, 12 devices, and 14 studies, with 1564 subjects.We demonstrate qEEG “batch effects”, providing harmonization methods to remove them.Multinational harmonized z-scores increase diagnostic accuracy of brain dysfunction.Data and software are available for norm and individual z-scores calculation.
Tr?ndle Marius、Wang Ying、Langer Nicolas、Milakhina Natalya S.、Hu Shiang、Virues-Alba Trinidad A.、Calzada-Reyes Ana、Villringer Arno、Paz-Linares Deirel、Dong Li、Aubert-Vazquez Eduardo、Galan-Garcia Lidice、Morales-Chacon Lilia、Valdes-Sosa Mitchell J.、Rudych Pavel、Yao Dezhong、Li Min、Bosch-Bayard Jorge F.、Bringas-Vega Maria L.、Lei Xu、Garcia-Agustin Daysi、Ochoa-Gomez John F.、Koenig Thomas、Valdes-Sosa Pedro Antonio、Tobon-Quintero Carlos A.、Abdul Rahman Muhammad Riddha Bin、Galler Janina R.、Abd Hamid Aini Ismafairus、Prichep Leslie S.、Areces-Gonzalez Ariosky、Omar Hazim、Abdullah Jafri Malin、Reza Faruque、Mohd Zulkifly Mohd Faizal Bin、Savostyanov Alexander N.、Evans Alan C.、Lopez-Naranjo Carlos
Department of Methods of Plasticity Research, Institute of Psychology, University of Zurich||University Research Priority Program ?°Dynamic of Healthy Aging?±, University of Zurich||Neuroscience Center Zurich (ZNZ)The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of ChinaDepartment of Methods of Plasticity Research, Institute of Psychology, University of Zurich||Neuroscience Center Zurich (ZNZ)||University Research Priority Program ?°Dynamic of Healthy Aging?±, University of ZurichLaboratory of Psychological Genetics at the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences||Laboratory of Psychophysiology of Individual Differences, Federal State Budgetary Scientific Institution Scientific Research Institute of Neurosciences and MedicineAnhui Provincial Key Laboratory of Multimodal Cognitive Computation, Key Laboratory of Intelligent Computing & Signal Processing of Ministry of Education, School of Computer Science and Technology, Anhui UniversityCuban Neuroscience CenterCuban Neuroscience CenterDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences||Department of Cognitive Neurology, University Hospital Leipzig||Center for Stroke Research, Charit¨|-Universit?tsmedizin BerlinThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China||Cuban Neuroscience CenterThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China||Research Unit of NeuroInformation, Chinese Academy of Medical Sciences||Sichuan Institute for Brain Science and Brain-Inspired IntelligenceCuban Neuroscience CenterCuban Neuroscience CenterDepartment of Clinical Neurophysiology, International Center for Neurological RestorationCuban Neuroscience CenterDepartment of Information Technologies Novosibirsk State University||Laboratory of Psychophysiology of Individual Differences, Federal State Budgetary Scientific Institution Scientific Research Institute of Neurosciences and Medicine||Federal Research Center for Information and Computational Technologies, Biomedical Data Processing LabThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China||Research Unit of NeuroInformation, Chinese Academy of Medical Sciences||School of Electrical Engineering, Zhengzhou UniversityThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China||Cuban Neuroscience Center||McGill Centre for Integrative Neuroscience, Ludmer Centre for Neuroinformatics and Mental Health, Montreal Neurological InstituteThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China||Cuban Neuroscience CenterSleep and NeuroImaging Center, Faculty of Psychology, Southwest UniversityThe Cuban center aging longevity and health||Cuban Neuroscience CenterGrupo Neuropsicolog¨aa y Conducta - GRUNECO, Faculty of Medicine, Universidad de Antioquia||Grupo de Neurociencias de Antioquia, Universidad de Antioquia, School of Medicine. Medell¨anUniversity Hospital of Psychiatry and Psychotherapy, University of BernThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China||Cuban Neuroscience CenterGrupo Neuropsicolog¨aa y Conducta - GRUNECO, Faculty of Medicine, Universidad de Antioquia||Research Department, Instituci¨?n Prestadora de Servicios de Salud IPS UniversitariaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia Universiti Sains Malaysia Health Campus||Brain and Behaviour Cluster, School of Medical Sciences, Universiti Sains Malaysia, Health Campus||School of Medical Imaging, Faculty of Health Sciences, Universiti Sultan Zainal AbidinDivision of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children United States Massachusetts General Hospital for ChildrenDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia Universiti Sains Malaysia Health Campus||Brain and Behaviour Cluster, School of Medical Sciences, Universiti Sains Malaysia, Health Campus||Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Health CampusResearch & Development, BrainScope Company, Inc.||Brain Research Laboratories, Department of Psychiatry (Ret.), NYU School of MedicineThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China||University of Pinar del R¨ao ?°Hermanos Saiz Montes de Oca?±Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia Universiti Sains Malaysia Health Campus||Brain and Behaviour Cluster, School of Medical Sciences, Universiti Sains Malaysia, Health Campus||Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Health CampusDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia Universiti Sains Malaysia Health Campus||Brain and Behaviour Cluster, School of Medical Sciences, Universiti Sains Malaysia, Health Campus||Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Health CampusDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia Universiti Sains Malaysia Health Campus||Brain and Behaviour Cluster, School of Medical Sciences, Universiti Sains Malaysia, Health Campus||Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Health CampusDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia Universiti Sains Malaysia Health Campus||Brain and Behaviour Cluster, School of Medical Sciences, Universiti Sains Malaysia, Health Campus||Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Health CampusHumanitarian Institute, Novosibirsk State University||Laboratory of Psychophysiology of Individual Differences, Federal State Budgetary Scientific Institution Scientific Research Institute of Neurosciences and Medicine||Laboratory of Psychological Genetics at the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of SciencesMcGill Centre for Integrative Neuroscience, Ludmer Centre for Neuroinformatics and Mental Health, Montreal Neurological InstituteThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China
神经病学、精神病学基础医学医学研究方法
ElectroencephalographyClinical neurosciencequantitative EEGEEG Cross-SpectrumRiemannian geometryBatch effectsz-scoreHarmonizationMahalanobis distance
Tr?ndle Marius,Wang Ying,Langer Nicolas,Milakhina Natalya S.,Hu Shiang,Virues-Alba Trinidad A.,Calzada-Reyes Ana,Villringer Arno,Paz-Linares Deirel,Dong Li,Aubert-Vazquez Eduardo,Galan-Garcia Lidice,Morales-Chacon Lilia,Valdes-Sosa Mitchell J.,Rudych Pavel,Yao Dezhong,Li Min,Bosch-Bayard Jorge F.,Bringas-Vega Maria L.,Lei Xu,Garcia-Agustin Daysi,Ochoa-Gomez John F.,Koenig Thomas,Valdes-Sosa Pedro Antonio,Tobon-Quintero Carlos A.,Abdul Rahman Muhammad Riddha Bin,Galler Janina R.,Abd Hamid Aini Ismafairus,Prichep Leslie S.,Areces-Gonzalez Ariosky,Omar Hazim,Abdullah Jafri Malin,Reza Faruque,Mohd Zulkifly Mohd Faizal Bin,Savostyanov Alexander N.,Evans Alan C.,Lopez-Naranjo Carlos.Harmonized-Multinational qEEG Norms (HarMNqEEG)[EB/OL].(2025-03-28)[2025-07-16].https://www.biorxiv.org/content/10.1101/2022.01.12.476128.点此复制
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