Rapid changes in Atlantic grey seal milk from birth to desertion
Rapid changes in Atlantic grey seal milk from birth to desertion
Abstract True seals have the shortest lactation periods of any group of placental mammal. Most are capital breeders that undergo short, intense lactations, during which they fast while transferring substantial proportions of their body reserves to their pups, which they then abruptly desert. Milk was collected from Atlantic grey seals (Halichoerus grypus) periodically from birth until near desertion. Milk protein profiles matured within 24 hours or less, indicating the most rapid transition from colostrum to mature phase lactation yet observed. There was an unexpected persistence of immunoglobulin G almost until weaning, potentially indicating prolonged trans-intestinal transfer of IgG. Among components of innate immune protection were found fucosyllactose and siallylactose that are thought to impede colonisation by pathogens and encourage an appropriate gut microbiome. These oligosaccharides decreased from early lactation to almost undetectable levels by weaning. Taurine levels were initially high, then fell, possibly indicative of taurine dependency in seals, and progressive depletion of maternal reserves. Metabolites that could signal changes in the mother’s metabolism of fats, such as nicotinamide and derivatives, rose from virtual absence, and acetylcarnitines fell. It is therefore possible that indicators of maternal metabolic strain exist that signal the imminence of desertion.
Burchmore Richard J.S.、Lowe Amanda D.、McGill Suzanne、Watson David G.、Kennedy Malcolm W.、Pomeroy P.P (Paddy)、Bawazeer Sami
Institute of Infection, Immunity and Inflammation, and Glasgow Polyomics, College of Medical, Veterinary and Life Sciences, University of GlasgowInstitute of Biodiversity, Animal Health & Comparative Medicine, and School of Life Sciences, Graham Kerr Building, College of Medical, Veterinary and Life Sciences, University of GlasgowInstitute of Infection, Immunity and Inflammation, and Glasgow Polyomics, College of Medical, Veterinary and Life Sciences, University of GlasgowStrathclyde Institute of Pharmacy and Biomedical Sciences, University of StrathclydeInstitute of Biodiversity, Animal Health & Comparative Medicine, and School of Life Sciences, Graham Kerr Building, College of Medical, Veterinary and Life Sciences, University of GlasgowSea Mammal Research Unit, Scottish Oceans Institute, University of St AndrewsStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde
动物学生物化学生理学
Atlantic grey sealHalichoerus grypusmilkcolostrumproteomicsmetabolomicsimmune factors
Burchmore Richard J.S.,Lowe Amanda D.,McGill Suzanne,Watson David G.,Kennedy Malcolm W.,Pomeroy P.P (Paddy),Bawazeer Sami.Rapid changes in Atlantic grey seal milk from birth to desertion[EB/OL].(2025-03-28)[2025-05-18].https://www.biorxiv.org/content/10.1101/170514.点此复制
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