Diet, pace of biological aging, and risk of dementia in the Framingham Heart Study
Diet, pace of biological aging, and risk of dementia in the Framingham Heart Study
ABSTRACT INTRODUCTIONWe tested the hypothesis that healthy diet protects against dementia because it slows the pace of biological aging. METHODSWe analyzed Framingham Offspring Cohort data (≥60y). We measured healthy diet using the Dietary Guideline for Americans (DGA, 3 visits 1991-2008), pace of aging using the DunedinPACE epigenetic clock (2005-2008), and incident dementia and mortality using records (compiled 2005-2018). RESULTSOf n=1,525 included participants (mean age 69.7, 54% female), n=129 developed dementia and n=432 died over follow-up. Greater DGA adherence was associated with slower DunedinPACE and reduced risks for dementia and mortality. Slower DunedinPACE was associated with reduced risks for dementia and mortality. Slower DunedinPACE accounted for 15% of the DGA association with dementia and 39% of the DGA association with mortality. DISCUSSIONFindings suggest that slower pace of aging mediates part of the relationship of healthy diet with reduced dementia risk. Monitoring pace of aging may inform dementia prevention.
Gu Yian、Belsky Daniel W.、Moffitt Terrie E.、Thomas Aline、Zhou Jiayi、Caspi Avshalom、Ryan Calen P、Sugden Karen
Taub Institute for Research on Alzheimer?ˉs Disease and the Aging Brain, Columbia University||Department of Neurology, Columbia University||Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University||Gertrude H. Sergievsky Center, Columbia UniversityButler Columbia Aging Center, Columbia University Mailman School of Public Health||Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia UniversityDepartment of Psychology and Neuroscience, Duke UniversityTaub Institute for Research on Alzheimer?ˉs Disease and the Aging Brain, Columbia University||Department of Neurology, Columbia UniversityButler Columbia Aging Center, Columbia University Mailman School of Public HealthDepartment of Psychology and Neuroscience, Duke UniversityButler Columbia Aging Center, Columbia University Mailman School of Public HealthDepartment of Psychology and Neuroscience, Duke University
神经病学、精神病学预防医学医学研究方法
Dietbiological ageDNA methylationdementiaall-cause mortalitymediationFraminghamCohortRisk factors in epidemiology
Gu Yian,Belsky Daniel W.,Moffitt Terrie E.,Thomas Aline,Zhou Jiayi,Caspi Avshalom,Ryan Calen P,Sugden Karen.Diet, pace of biological aging, and risk of dementia in the Framingham Heart Study[EB/OL].(2025-03-28)[2025-06-05].https://www.medrxiv.org/content/10.1101/2023.05.24.23290474.点此复制
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