7例进行性核上性麻痹的临床及影像学特点分析
linical and imaging features of 7 patients with Progressive supranuclear palsy
目的 总结临床诊断为进行性核上性麻痹(PSP)病例，并结合文献分析其临床及影像学特点。方法 回顾性分析7例进行核上性麻痹患者的临床资料。结果 7例患者均起病隐匿，首发为运动障碍/帕金森综合征表现，渐加重，中晚期出现垂直性核上型眼肌麻痹，假性球麻痹和认知障碍。早期头颅MRI缺乏特异性；晚期2例中脑被盖部萎缩，有轴位“牵牛花征”和矢状位“蜂鸟征”典型表现，神经保护剂及对症治疗无明显好转。结论 进行性核上性麻痹的早期临床表现应引起重视，影像学特异性改变有助诊断。
IObjective To analyze the clinical and imaging features in patients with progressive supranuclear palsy(PSP). Methods The clinical and imaging data of seven patients with PSP were analyzed retrospectively. Results The symptoms of all PSP patients appeared insidiously and progressed slowly. All patients had general characters of parkinsonism at the beginning, developed the classic vertical supranuclear ophthalmoparesis, pseudobulbar paralysis and cognitive impairment finally. The MRI of early stage showed no specificity. Two cases showed classic hummingbird sign and Morning Glory Sign. It brought no obvious improvement to accept neuroprotective agent and symptomatic treatment. Conclusions Early symptoms and signs of PSP need to be aware of. Typical signs of MRI in PSP are helpful in diagnosis.
徐俊、江炜炜、朱银伟、芮晓东、陈俊
神经病学、精神病学
神经病学进行性核上性麻痹临床特点影像学
Neurologyprogressive supranuclear palsyclinical featureImaging
徐俊,江炜炜,朱银伟,芮晓东,陈俊.7例进行性核上性麻痹的临床及影像学特点分析[EB/OL].(2010-06-25)[2025-07-17].http://www.paper.edu.cn/releasepaper/content/201006-496.点此复制
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