Trivalent NDV-HXP-S vaccine protects against phylogenetically distant SARS-CoV-2 variants of concern in mice
Trivalent NDV-HXP-S vaccine protects against phylogenetically distant SARS-CoV-2 variants of concern in mice
Abstract Equitable access to vaccines is necessary to limit the global impact of the coronavirus disease 2019 (COVID-19) pandemic and the emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. In previous studies, we described the development of a low-cost vaccine based on a Newcastle Disease virus (NDV) expressing the prefusion stabilized spike protein from SARS-CoV-2, named NDV-HXP-S. Here, we present the development of next-generation NDV-HXP-S variant vaccines, which express the stabilized spike protein of the Beta, Gamma and Delta variants of concerns (VOC). Combinations of variant vaccines in bivalent, trivalent and tetravalent formulations were tested for immunogenicity and protection in mice. We show that the trivalent preparation, composed of the ancestral Wuhan, Beta and Delta vaccines, substantially increases the levels of protection and of cross-neutralizing antibodies against mismatched, phylogenetically distant variants, including the currently circulating Omicron variant.
Schotsaert Michael、Mart¨anez Jose Luis、Liu Yonghong、Carre?o Juan Manuel、Mena Ignacio、McCroskery Stephen、Coughlan Lynda、Krammer Florian、Sun Weina、Slamanig Stefan、Garc¨aa-Sastre Adolfo、Gonz¨￠lez-Dom¨anguez Irene、Palese Peter、Singh Gagandeep、Singh Gagandeep、Lai Tsoi Ying、Lemus Nicholas
Department of Microbiology, Icahn School of Medicine at Mount Sinai||Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount Sinai||Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology and Immunology, University of Maryland School of Medicine||Center for Vaccine Development and Global Health (CVD), University of Maryland School of MedicineDepartment of Microbiology, Icahn School of Medicine at Mount Sinai||Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount Sinai||Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai||Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai||Department of Medicine, Icahn School of Medicine at Mount Sinai||The Tisch Cancer Institute, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount Sinai||Department of Medicine, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount Sinai||Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount Sinai
预防医学生物科学现状、生物科学发展生物科学研究方法、生物科学研究技术
Cross-protectionpandemic preparednessneutralizing antibodieslow-cost vaccine platformmultivalent vaccine
Schotsaert Michael,Mart¨anez Jose Luis,Liu Yonghong,Carre?o Juan Manuel,Mena Ignacio,McCroskery Stephen,Coughlan Lynda,Krammer Florian,Sun Weina,Slamanig Stefan,Garc¨aa-Sastre Adolfo,Gonz¨￠lez-Dom¨anguez Irene,Palese Peter,Singh Gagandeep,Singh Gagandeep,Lai Tsoi Ying,Lemus Nicholas.Trivalent NDV-HXP-S vaccine protects against phylogenetically distant SARS-CoV-2 variants of concern in mice[EB/OL].(2025-03-28)[2025-06-14].https://www.biorxiv.org/content/10.1101/2022.03.21.485247.点此复制
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