快速老化模型小鼠SAMP8行为学的增龄性变化
ge-related Changes in behavior of Senescence Accelerated Mouse SAMP8
目的 对SAMP8老化征象和学习记忆能力的增龄性变化进行比较系统的研究，为利用该模型进行其他研究提供实验依据。方法 选用2、4、6、8、10、12月龄SAMP8，以同龄正常老化的SAMR1为对照，应用老化度评分和Morris水迷宫测试SAMP8的老化度和学习记忆能力的增龄性变化。结果 SAMP8在4月龄出现明显的老化体征，并在6月龄开始表现出空间学习记忆障碍。结论 SAMP8在成熟期（4-6月）过后发生了快速老化，证实SAMP8是研究衰老和老年性痴呆的理想模型。
Objective To observe the age-related changes in aging sign and symptoms, and learning and memory of senescence accelerated mouse SAMP8. Method selecting Senescence Accelerated Mouse SAMP8 and normal control SAMR1 at six ages from 2th month to 12th month, age-related changes in aging and learning and memory were studied by “ the scores of aging” and Water Morrris Maze. Results The SAMP8 appeared obvious aging sign and symptoms at 4-month old. Compared to SAMR1 control group, SAMP8 mouse showed significant impairments on learning and memory in hidden platform trial at age of 8th month, 10th month and 12th month. In probe trial and reversal trial, SAMP8 began to show significant impairments on learning and memory at age of 6month. Conclusion The results showed that SAMP8 began to accelerate senescense after mature period (4-6month) and appeared learning and memory disorder at 6-8 months old. It manifested that SAMP8 was an ideal model for investigating the mechanism of aging and senile dementia.
韩景献、于建春、褚芹 、于涛、潘建明
基础医学神经病学、精神病学生理学
快速老化模型小白鼠（SAM）SAMP8老化Morris水迷宫学习记忆能力
Senescence Accelerated MouseSAMP8AgingMorris water mazeLearning and Memory
韩景献,于建春,褚芹 ,于涛,潘建明.快速老化模型小鼠SAMP8行为学的增龄性变化[EB/OL].(2006-12-20)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/200612-314.点此复制
评论