主要穹窿蛋白在病毒感染过程中作用的研究进展

Multidrug-resistance cancer cells have been shown overexpression of major vault protein, barrel-shaped complex vaults are composed of three proteins, major vault protein, vault poly (ADP-ribose) polymerase, and telomerase-associated protein 1, and small untranslated RNAs.Vaults can transport particles like drug between cytoplasm and nuclear. Recent years, reports have shown that major vault protein functions in cellular progress. Major vault protein can interact with endogenous phosphatase and tensin homolog (PTEN) with the help of calcium, then it can participate in the phosphoinositide 3-kinase pathway and cell growth. Moreover, some researches have confirmed that major vault protein can reduce the replication of virus through induction of the expression of type-I interferon and participation of proinflammatory response.