m6A甲基化阅读器在生殖发育中的作用及调节机制
he role and regulatory mechanism of m6A methylation reader in reproductive development
N6-甲基腺苷(N6-methyladenosine,m6A)甲基化是真核细胞中最为广泛和丰富的RNA修饰类型。m6A甲基化阅读器是一类识别并结合靶mRNA上m6A甲基化位点的RNA结合蛋白。本文总结了m6A甲基化修饰阅读器的生物学功能、调节机制以及其在配子发生、胚胎发育以及生殖相关疾病中的最新研究进展。
N6-methyladenosine (m6A) methylation is the most prevalent and abundant type of RNA modification in eukaryotic cells. m6A methylation readers are a class of RNA-binding proteins that recognize and bind m6A methylation sites on target mRNAs. This review summarizes the latest research progress on the biological functions, regulatory mechanisms, and roles of m6A readers in gametogenesis, embryonic development and reproductive-related diseases.
李丹、樊佳慧
分子生物学遗传学细胞生物学
m6A甲基化阅读器配子发生胚胎发育生殖疾病
m6A methylation readergametogenesisembryonic developmentreproductive diseases
李丹,樊佳慧.m6A甲基化阅读器在生殖发育中的作用及调节机制[EB/OL].(2022-04-19)[2025-07-02].http://www.paper.edu.cn/releasepaper/content/202204-227.点此复制
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