Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar
Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar
Abstract A number of studies reported that influenza vaccination is associated with lower risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and/or coronavirus disease 2019 (COVID-19) morbidity and mortality. We conducted a matched, test-negative, case-control study to estimate effectiveness of influenza vaccination, using Abbott’s quadrivalent Influvac Tetra vaccine, against SARS-CoV-2 infection and against severe COVID-19. The study was implemented on a population of 30,774 healthcare workers (HCWs) in Qatar during the 2020 annual influenza vaccination campaign, between September 17, 2020 and December 31, 2020, before introduction of COVID-19 vaccination. The median age in the matched samples was 36 years (interquartile range (IQR), 32-44) for cases and 35 years (IQR, 32-42) for controls. The median duration between influenza vaccination and the PCR test was 43 days (IQR, 29-62). The estimated effectiveness of influenza vaccination against SARS-CoV-2 infection >14 days after receiving the vaccine was 29.7% (95% CI: 5.5-47.7%). The estimated effectiveness of influenza vaccination against any severe, critical, or fatal COVID-19 was 88.9% (95% CI: 4.1-98.7%). Sensitivity analyses confirmed main analysis results. Recent influenza vaccination is associated with an appreciable reduction in the risk of SARS-CoV-2 infection and COVID-19 severity.
Bougmiza Iheb、Al-Romaihi Hamad Eid、Al-Thani Mohamed H.、Bertollini Roberto、Abu-Raddad Laith J.、Abdeen Sami、Shaik Riyazuddin Mohammad、Ayoub Houssein H.、Al-Khal Abdullatif、Chemaitelly Hiam、Latif Ali Nizar、Kaleeckal Anvar Hassan、Tayar Elias、Alah Muna Abed
Community Medicine Department, Primary Health Care Corporation||Community Medicine Department, College of Medicine, Sousse UniversityMinistry of Public HealthMinistry of Public HealthMinistry of Public HealthInfectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University||World Health Organization Collaborating Centre for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis, Weill Cornell Medicine¨CQatar, Cornell University||Department of Population Health Sciences, Weill Cornell Medicine, Cornell University||Department of Public Health, College of Health Sciences, QU Health, Qatar UniversityCommunity Medicine Department, Hamad Medical CorporationBusiness Intelligence and Operational Performance Unit, Hamad Medical CorporationMathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences, Qatar UniversityCommunity Medicine Department, Hamad Medical CorporationInfectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University||World Health Organization Collaborating Centre for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis, Weill Cornell Medicine¨CQatar, Cornell University||Department of Population Health Sciences, Weill Cornell Medicine, Cornell UniversityBusiness Intelligence and Operational Performance Unit, Hamad Medical CorporationBusiness Intelligence and Operational Performance Unit, Hamad Medical CorporationCommunity Medicine Department, Hamad Medical CorporationCommunity Medicine Department, Hamad Medical Corporation
预防医学医学研究方法
influenzaCOVID-19vaccinetest-negativecase-controlimmunityepidemiology
Bougmiza Iheb,Al-Romaihi Hamad Eid,Al-Thani Mohamed H.,Bertollini Roberto,Abu-Raddad Laith J.,Abdeen Sami,Shaik Riyazuddin Mohammad,Ayoub Houssein H.,Al-Khal Abdullatif,Chemaitelly Hiam,Latif Ali Nizar,Kaleeckal Anvar Hassan,Tayar Elias,Alah Muna Abed.Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2022.05.09.22274802.点此复制
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