铁代谢与细胞周期调控的研究进展

Iron is an essential trace Element for cell proliferation; iron is involved in process of DNA synthesis to ensure the cells have a smooth transition from G1 phase to S phase. Iron metabolism disorders can cause the cell cycle changes even cell apoptosis. Normal levels of iron can activate cytokines and cell cycle-dependent kinase cyclin-dependent kinases (cdks) to promote the synthesis of DNA and cell cycle protein expression, and this can make sure that the cells can proliferate smoothly. Tumor cells' proliferation requires a large amount of iron, iron chelating can reduce the iron content of tumor cells and enhance the expression of p53, causing the cells stopped in the S phage or apoptosis. Study the mechanism between iron metabolism and cell cycle regulation has great theoretical and practical significance.