The Filter Detection Task for measurement of breathing-related interoception and metacognition
The Filter Detection Task for measurement of breathing-related interoception and metacognition
Abstract The study of the brain’s processing of sensory inputs from within the body (‘interoception’) has been gaining rapid popularity in neuroscience, where interoceptive disturbances are thought to exist across a wide range of chronic physiological and psychological conditions. Here we present a task and analysis procedure to quantify specific dimensions of breathing-related interoception, including interoceptive sensitivity (accuracy), decision bias, metacognitive bias, and metacognitive performance. Two major developments address some of the challenges presented by low trial numbers in interoceptive experiments: (i) a novel adaptive algorithm to maintain task performance at 70-75% accuracy; (ii) an extended hierarchical metacognitive model to estimate regression parameters linking metacognitive performance to relevant (e.g. clinical) variables. We demonstrate the utility of the task and analysis developments, using both simulated data and three empirical datasets. This methodology represents an important step towards accurately quantifying interoceptive dimensions from a simple experimental procedure that is compatible with clinical settings.
Marlow Lucy、Finnemann Johanna、Keur-Huizinga Laura、Nanz Laura、Fleming Stephen M.、Finnegan Sarah、Garfinkel Sarah N.、Harrison Samuel J.、Allen Micah、Marino Stephanie、Harrison Olivia K.、Stephan Klaas E.、Pattinson Kyle T. S.
Nuffield Department of Clinical Neurosciences, University of OxfordCambridge Psychiatry, University of CambridgeCambridge Psychiatry, University of CambridgeTranslational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH ZurichWellcome Centre for Human Neuroimaging, University College London||Max Planck Centre for Computational Psychiatry and Ageing Research, University College London||Department of Experimental Psychology, University College LondonNuffield Department of Clinical Neurosciences, University of OxfordBrighton and Sussex Medical School, University of SussexTranslational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH ZurichAarhus Institute of Advanced Studies, Aarhus University||Center of Functionally Integrative Neuroscience, Aarhus University Hospital||Cambridge Psychiatry, University of CambridgeTranslational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH ZurichTranslational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich||Nuffield Department of Clinical Neurosciences, University of Oxford||School of Pharmacy, University of OtagoTranslational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich||Max Planck Institute for Metabolism ResearchNuffield Department of Clinical Neurosciences, University of Oxford
基础医学生理学自然科学研究方法
interoceptionbreathinginspiratory resistancemetacognition
Marlow Lucy,Finnemann Johanna,Keur-Huizinga Laura,Nanz Laura,Fleming Stephen M.,Finnegan Sarah,Garfinkel Sarah N.,Harrison Samuel J.,Allen Micah,Marino Stephanie,Harrison Olivia K.,Stephan Klaas E.,Pattinson Kyle T. S..The Filter Detection Task for measurement of breathing-related interoception and metacognition[EB/OL].(2025-03-28)[2025-05-24].https://www.biorxiv.org/content/10.1101/2020.06.29.176941.点此复制
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