磷酸酯类聚合物的合成及其生物应用

Functionalized polyphosphoesters have attracted more and more attention in the last decade and have currently been applied in drug/ gene delivery, tissue engineering and so on. This review briefly summarizes the structural characteristics of polyphosphoesters and the controlled synthetic methods, which provide access to novel and complex polymer structures. The article focuses on the various types of synthetic polyphosphoesters such as linear, star and hyperbranched derivatives, particularly those polyphosphoester derivatives that applied in biological fields are highlighted. In addition, on the basis of current research in the fields, this paper presents several representative topologies of polyphosphoesters and their application in drug/ gene deliveries and tissue engineering. At last we propose the prospects of polyphosphoesters development in life sciences and the goal of this review is to enable better communication with other scientists in this field.