重组人p53腺病毒的应用前瞻

Malignant transformation is closely related to gene mutations. The tumor suppressor gene p53 codes for a transcription factor, P53 p rotein, plays a critical regulation role in oncogene expression, inhibinting vascular proliferation,DNA synthesis and repair systems, cell apoptosis and multidrug resistance. It has been demonstrated that p53 mutation,translocation,fusion,insertion and deletion occurs in more than 50% of cancer cells. which is thought to play a crucial role in malignant transformation. p53 gene therapy approaches aiming at a direct correction of the specific molecular defect in p53-mutated malignant cells and enhancing sensitivity of chemtherapy and radiotherapy. In this review, we discussed the current advances and problems in this field, focusing on adenovirus-mediated wild-type p53gene therapy.