含肉桂醛的pH响应性聚碳酸酯的制备及其性能研究

innamaldehyde-containing cyclocarbonate monomer (CAMPC) was synthesized from cinnamaldehyde, pentaerythritol and ethyl chloroformate. Using DBU as a catalyst and mPEG113 as a macroinitiator, block copolymers mPEG-b-PCAMPC with different degrees of polymerization of CAMPC were obtained via ring-opening polymerization. The chemical structure, degree of polymerization, molecular weight and molecular weight distribution of the polymer were analyzed by 1H NMR and GPC. The polymer self-assembled into micelles in water and its critical micelle concentration (CMC) was measured by a fluorescence spectrometer. The particle size and pH response of polymer micelles were analyzed using DLS and fluorescence spectrometers. The controllable release of Nile red at different pH was further investigated. The results showed that the polymer has good pH responsiveness and had potential application value in the field of drug delivery.