慢性焦虑应激大鼠行为学的测评变化
Evaluation of changes of behavior in rats with chronic stress-induced anxiety theory
目的 本研究以慢性焦虑应激大鼠为载体，探讨其焦虑状态及行为学的变化，旨在探索能较好模拟广泛性焦虑障碍的动物模型。方法 采用慢性情绪应激的方法建立焦虑大鼠模型，以国际公认的高架十字迷宫试验对其行为学进行评价。结果 应激后大鼠处于易激惹的状态，表现出频繁的修饰和攻击行为，经高架十字迷宫测试发现大鼠较少进入并停留于开放臂中，倾向于探究封闭臂，且在封闭臂的停留时间延长。结论 不确定性空瓶刺激作为一种慢性心理应激模型，从病因学上较好模拟了广泛性焦虑障碍的发病状态和行为学表现。
Objective in this study, chronic anxiety stress in rats as the carrier, to explore its change state of anxiety and behavior, in order to explore the animal model could simulate generalized anxiety disorder. Methods the model of chronic emotional stress in anxiety rats, with the internationally recognized the elevated plus-maze test on its behavior evaluation. Results after stress in rats in irritable state, exhibited frequent modification and aggressive behavior, the elevated plus-maze test found fewer rats enter and stay in the open arm, and tended to explore the closed arms, and stay in the closed arm. Conclusion uncertainty stimulation of empty bottle as a chronic psychological stress model, from etiology better simulated the generalized anxiety disorder state and behavior
唐启盛、李宁、赵瑞珍
神经病学、精神病学基础医学生物科学研究方法、生物科学研究技术
焦虑模型行为学慢性情绪应激高架十字迷宫
nxiety modelethologyChronic emotional stressThe elevated plus maze
唐启盛,李宁,赵瑞珍.慢性焦虑应激大鼠行为学的测评变化[EB/OL].(2013-03-13)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201303-495.点此复制
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