基底外侧杏仁核异质性调节海马长时程增强

【Objective】To further explore the modulatory effects of basolateral amygdala（BLA）on hippocampal synaptic plasticity in rat.【Methods】Using neuro-electrophysiological procedure, the Long-term potentiation（LTP）, which was induced by theta burst stimulus applied 30 s before the relatively low level or high level BLA priming stimulation, was measured in the ipsilateral perforant path (PP)-DG and contralateral ventral hippocampal commisure (vHC)-CA1 pathways in anaesthetized rats. 【Results】In comparison with the control, the low level of BLA priming stimulation enhanced but the high level of BLA priming stimulation impaired DG LTP; however, both levels of BLA priming stimulation impaired CA1 LTP【Conclusion】These findings suggest that the BLA modulates hippocampal synaptic plasticity in its activation degree and hippocampal subregions.