抗癫痫药物拉科酰胺的合成路线综述
Summary of symthetic routes for a kind of anti-epileptic drug lacosmide
拉科酰胺是用于治疗癫痫和神经性疼痛的新药，具有抗惊厥和镇痛的双重作用，它可选择性促进钠通道缓慢失活并调节塌陷反应介导蛋白-2(CRMP-2)，而CRMP-2可能减慢甚至阻止癫痫发作以及减轻糖尿病的神经性疼痛。本文简单介绍了这种抗癫痫药物，对拉科酰胺的合成路线进行归纳总结，并对各合成方法的优缺点进行了分析。
Lacosamide is a new kind of drug in the treatment of epilepsy and neuropathic pain with anticonvulsant and analgesic dual functions. It can selectively enhance slow inactivation of voltage-gated sodium channels and interacts with collapsin response mediator protein-2(CRMP-2), which may slow or even prevent seizures and relieve diabetic neuropathic pain. This article mainly introduced this kind of epilepsy drug, comprehensively listed and analysed the synthesis routes of it according to the different raw materials.
王兴涌、于瑞
药学制药化学工业
拉科酰胺抗癫痫药合成路线综述
lacosamideanti-epileptic drugsynthetic routesummary
王兴涌,于瑞.抗癫痫药物拉科酰胺的合成路线综述[EB/OL].(2011-09-02)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201109-37.点此复制
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