Lessons learned from implementation of interferon-gamma release assay to screen for latent tuberculosis infection in a large multicenter observational cohort study in Brazil
Lessons learned from implementation of interferon-gamma release assay to screen for latent tuberculosis infection in a large multicenter observational cohort study in Brazil
Abstract BackgroundInterferon-gamma release assay (IGRA) has emerged as a useful tool in identifying latent tuberculosis infection (LTBI). This assay can be performed through testing platforms, such as QuantiFERON-TB Gold Plus (QFT?-Plus). This in vitro test has been incorporated by several guidelines worldwide and has recently been considered for the diagnosis of LTBI by the World Health Organization (WHO). The possibility of systematically implementing IGRAs such as QFT?-Plus in centers that perform LTBI screening has been accelerated by the decreased availability of tuberculin skin testing (TST) in several countries. Nevertheless, the process to implement IGRA testing in routine clinical care has many gaps. MethodsThe study utilized the expertise acquired by the laboratory teams of the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil consortium during study protocol implementation of LTBI screening of TB close contacts. ResultsRePORT-Brazil includes clinical research sites from Brazilian cities and is the largest multicenter cohort of TB close contacts to date in the country. Operational and logistical challenges faced during IGRA implementation in all four study laboratories are described, as well as the solutions that were developed and led to the successful establishment of IGRA testing in RePORT-Brazil. ConclusionsThe problems identified and resolved in this study can assist laboratories implementing IGRAs, in addition to manufacturers of IGRAs providing effective technical support. This will facilitate the implementation of IGRA testing in countries with a high TB burden, such as Brazil. ImportanceThe interferon-gamma release assay (IGRA) has emerged as a useful tool in identifying persons with latent tuberculosis infection (LTBI). Although the implementation of IGRAs is of utmost importance, to our knowledge, there is scarce information on identification of logistical and technical challenges of systematic screening of for LTBI on a large scale. Thus, the problems identified and resolved in this study can assist laboratories implementing IGRAs, in addition to manufacturers of IGRAs providing effective technical support. This will facilitate the implementation of IGRA testing in countries with a high TB burden, such as Brazil.
Souza Alexandra B.、Gomes-Silva Adriano、Benjamin Aline、Kritski Afranio L.、Rolla Valeria C.、the RePORT Brazil Consortium、Cavalcante Solange、Ibiapina Hiochelson N.S.、Spener-Gomes Renata、Arriaga Mar¨aa B.、Cordeiro-Santos Marcelo、Turner Megan M.、Figueiredo Marina C.、Costa Allyson G.、Rocha Michael S.、Andrade Alice M.S.、Silva Elisangela C.、Carvalho Brenda K.S.、Sterling Timothy R.、Durovni Betina、Ara¨2jo-Pereira Mariana、Andrade Bruno B.、Moreira Adriana S.R.、Oliveira Jamile G.
Instituto de Pesquisa Cl¨anica Carlos Borborema, Funda??o de Medicina Tropical Doutor Heitor Vieira Dourado||Programa de P¨?s-Gradua??o em Medicina Tropical, Universidade do Estado do AmazonasInstituto Nacional de Infectologia Evandro Chagas, Funda??o Oswaldo CruzInstituto Nacional de Infectologia Evandro Chagas, Funda??o Oswaldo CruzPrograma Acad¨omico de Tuberculose, Faculdade de Medicina, Universidade Federal do Rio de JaneiroInstituto Nacional de Infectologia Evandro Chagas, Funda??o Oswaldo CruzInstituto Nacional de Infectologia Evandro Chagas, Funda??o Oswaldo Cruz||Secretaria Municipal de Sa¨2de do Rio de JaneiroInstituto de Pesquisa Cl¨anica Carlos Borborema, Funda??o de Medicina Tropical Doutor Heitor Vieira Dourado||Programa de P¨?s-Gradua??o em Medicina Tropical, Universidade do Estado do AmazonasInstituto de Pesquisa Cl¨anica Carlos Borborema, Funda??o de Medicina Tropical Doutor Heitor Vieira Dourado||Programa de P¨?s-Gradua??o em Medicina Tropical, Universidade do Estado do AmazonasLaborat¨?rio de Inflama??o e Biomarcadores, Instituto Gon?alo Moniz, Funda??o Oswaldo Cruz||Faculdade de Medicina, Universidade Federal da Bahia||Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) InitiativeInstituto de Pesquisa Cl¨anica Carlos Borborema, Funda??o de Medicina Tropical Doutor Heitor Vieira Dourado||Programa de P¨?s-Gradua??o em Medicina Tropical, Universidade do Estado do Amazonas||Faculdade de Medicina, Universidade Nilton LinsDivision of Infectious Diseases, Department of Medicine, Vanderbilt University School of MedicineDivision of Infectious Diseases, Department of Medicine, Vanderbilt University School of MedicineInstituto de Pesquisa Cl¨anica Carlos Borborema, Funda??o de Medicina Tropical Doutor Heitor Vieira Dourado||Programa de P¨?s-Gradua??o em Medicina Tropical, Universidade do Estado do Amazonas||Escola de Enfermagem de Manaus, Universidade Federal do Amazonas||Diretoria de Ensino e Pesquisa, Funda??o Hospitalar de Hematologia e Hemoterapia do AmazonasMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative||Instituto Brasileiro para Investiga??o da Tuberculose, Funda??o Jos¨| SilveiraLaborat¨?rio de Inflama??o e Biomarcadores, Instituto Gon?alo Moniz, Funda??o Oswaldo Cruz||Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) InitiativePrograma Acad¨omico de Tuberculose, Faculdade de Medicina, Universidade Federal do Rio de Janeiro||Centro de Bioci¨oncias e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro||Funda??o Sa¨2de do Estado do Rio de Janeiro, Secretaria Estadual de Sa¨2de do Estado do Rio d JaneiroInstituto de Pesquisa Cl¨anica Carlos Borborema, Funda??o de Medicina Tropical Doutor Heitor Vieira Dourado||Programa de P¨?s-Gradua??o em Medicina Tropical, Universidade do Estado do AmazonasDivision of Infectious Diseases, Department of Medicine, Vanderbilt University School of MedicineInstituto Nacional de Infectologia Evandro Chagas, Funda??o Oswaldo Cruz||Secretaria Municipal de Sa¨2de do Rio de JaneiroLaborat¨?rio de Inflama??o e Biomarcadores, Instituto Gon?alo Moniz, Funda??o Oswaldo Cruz||Faculdade de Medicina, Universidade Federal da Bahia||Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) InitiativeLaborat¨?rio de Inflama??o e Biomarcadores, Instituto Gon?alo Moniz, Funda??o Oswaldo Cruz||Faculdade de Medicina, Universidade Federal da Bahia||Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) InitiativePrograma Acad¨omico de Tuberculose, Faculdade de Medicina, Universidade Federal do Rio de JaneiroSecretaria Municipal de Sa¨2de do Rio de Janeiro
医药卫生理论医学研究方法预防医学
TuberculosisIGRAQuantiFERON-PlusLTBIScreeningQuality control
Souza Alexandra B.,Gomes-Silva Adriano,Benjamin Aline,Kritski Afranio L.,Rolla Valeria C.,the RePORT Brazil Consortium,Cavalcante Solange,Ibiapina Hiochelson N.S.,Spener-Gomes Renata,Arriaga Mar¨aa B.,Cordeiro-Santos Marcelo,Turner Megan M.,Figueiredo Marina C.,Costa Allyson G.,Rocha Michael S.,Andrade Alice M.S.,Silva Elisangela C.,Carvalho Brenda K.S.,Sterling Timothy R.,Durovni Betina,Ara¨2jo-Pereira Mariana,Andrade Bruno B.,Moreira Adriana S.R.,Oliveira Jamile G..Lessons learned from implementation of interferon-gamma release assay to screen for latent tuberculosis infection in a large multicenter observational cohort study in Brazil[EB/OL].(2025-03-28)[2025-04-26].https://www.medrxiv.org/content/10.1101/2021.08.10.21261605.点此复制
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