bFGF负载胶原-纳米微晶纤维素多孔支架的制备及性能

Rod-like cellulose nanocrystals (CNCs) were manufactured and used to reinforce collagen scaffolds, to prepare a novel structure of composite scaffold. Collagen is the main component of skin and connective tissue found exclusively in body. The CNCs-loaded collagen scaffolds had improved structural stabilities. Structural stabilities are essential considerations for the design of composite in the field of tissue engineering. We have used a variety of experimental techniques to investigate the properties of the collagen/CNCs scaffolds at different mixing proportion. The objective was to observe the differences of collagen scaffold and collagen/CNCs scaffold in the swelling behaviour and thermostability. In addition, we describe the incorporation of bFGF-gelatin microspheres into collagen/CNCs scaffolds and study the release kinetics of basic fibroblast growth factor (bFGF) as a function of scaffold properties. With these abilities indicate that our new composite scaffold have good potential in the field of skin tissue engineering.