姜黄素调节转录因子抗肿瘤机制

bstract Curcumin is a polyphenol derived from Curcuma longa. Over the last few years, a number of studies have provided evidence of its main pharmacological properties including, wound healing activities, antimicrobial, antiviral, immunomodulatory, antioxidant and anti-inflammatory. More recent data provide interesting insights into the effect of this compound on cancer prevention and therapy. Most human malignancies are driven by chromosomal translocations or other genetic alterations. Extensive research has addressed the therapeutic potential of curcumin, a relatively non-toxic plant. The mechanisms implicated are diverse and appear to involve a combination of cell signaling pathways at multiple levels. In the present review we discuss how curcumin targets transcription factors regulatory molecules to assert anti-proliferative and/or apoptotic effects in cancer cells. Taken together, this review seeks to summarize the unique properties of curcumin that may be exploited for successful clinical cancer prevention.