hinese Color Nest Project (CCNP)i: Growing Up in China

Abstract: To face the challenges of keeping healthy in increasing population sizes ofboth ageing and developing people in China, a fundamental request from the publichealth is the development of lifespan normative trajectories of brain and behavior. Thispaper introduces the Chinese Color Nest Project (CCNP 2013–2022), a large-scale tenyearprogram of modeling brain and behavioral trajectories for human lifespan (6–85years old). We plan to gradually collect the behavioral and brain imaging data at agesacross the lifespan on nationwide and depict the normal trajectory of Chinese braindevelopment across the lifespan, based on the accelerated longitudinal design in thecoming next 10 years starting at 2013. Various psychiatric disorders have beendemonstrated highly relevant to abnormal events during the neurodevelopment regardingtheir onset ages of first episodes. Therefore, delineation of normative growth curves ofbrain and cognition in typically developing children is extremely useful for monitoring,early detecting and intervention of various neurodevelopmental disorders. In this paper,we detailed the developing part of CCNP, devCCNP. It tracked 192 healthy children andadolescents (6–18 years old) in Beibei district of Chongqing for the first 5 years of thefull CCNP cohort (2013–2017). To demonstrate the feasibility of implementing the longtermfollow-up of CCNP, we here comprehensively document devCCNP in terms of itsexperimental design, sample strategies, data acquisition and storage as well as somepreliminary results and data sharing roadmap for future. Specifically, we first describe theaccelerated longitudinal sampling design as well as its exact ratio of sample dropping offduring the data collection. Second, we present several initial findings such as canonicalgrowth curves of cortical surface areas of a set of well-established large-scale functionalnetworks of the human brain. Finally, together with records generated by manypsychological and behavioral tests, we will provide an individual growing-up report foreach family participating the program, initiating the potential guidance on the individualacademic and social development. The resources introduced in the current work canprovide first-hand data for a series of coming Chinese brain development studies, such asChinese Standard MRI Brain Templates, Normative Growth Curves of Chinese Brain andCognition as well as Mapping of Language Areas in Chinese Developing Brain. Thesewould not only offer normative references of the atypical brain and cognitiondevelopment for Chinese population but also serve as a strong force on accelerating thepace of integrating Chinese brain development into the national brain program or ChineseBrain Project.