急性早幼粒细胞白血病的miRNA表达与预后
Expression profile of miRNA and prognosis in acute promyelocytic leukemia
microRNA(miRNA)是一类内源性非编码RNA，通过转录后水平调节靶基因的表达。研究发现，miRNA的表达与急性白血病的发生、发展和临床特征关系密切。尽管因为靶向治疗药物的出现，急性早幼粒细胞白血病（APL）的完全缓解率很高，但仍有部分患者复发耐药。而目前缺乏预测APL复发耐药的标记物。最近的一些研究发现，miRNA的表达可能预测白血病对药物的反应及复发。本文就miRNA的表达与APL的预后关系进行综述。
microRNA (miRNA), a type of endogenous non coding RNA, regulate target gene expression by post transcriptional level. Previous study showed that miRNA expression has close relationship with development, progression and clinical features. Although the occurrence of targeting drugs, the complete remission of acute promyelocytic leukemia (APL) is high. But, there are still drug-resistance and recurrence. However, the prognosis marker to predict the recurrence and drug-resistance is lack. Recent studies suggested that miRNA might predict the drug reaction and relapsed of APL.
李英花、周晋、李慧波
基础医学肿瘤学内科学
急性早幼粒细胞白血病microRNA预后
cut promyelocytic leukemiamicroRNAprognosis
李英花,周晋,李慧波.急性早幼粒细胞白血病的miRNA表达与预后[EB/OL].(2016-06-03)[2025-08-16].http://www.paper.edu.cn/releasepaper/content/201606-294.点此复制
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