中国40~65岁女性围绝经期综合征发生率的Meta分析
Incidence of Perimenopausal Syndrome in Chinese Women Aged 40 to 65 Years：a Meta-analysis
背景??随着我国经济社会的飞速发展，居民生活水平和自我健康保健意识显著提升，我国人口平均预期寿命逐渐延长，围绝经期女性人群逐渐庞大，围绝经期女性健康管理也变得愈发重要。围绝经期综合征可见于40~65岁女性群体，会严重影响患者的身心健康和生活质量。目的??系统评价我国40~65岁女性人群围绝经期综合征的发生率。方法??计算机检索PubMed、Embase、WebofScience、中国知网、万方数据知识服务平台、中国生物医学文献数据库和维普网，收集有关中国40~65岁女性围绝经期综合征发生情况的横断面研究，检索时间设置为建库至2023-02-01。由2名研究人员独立筛选文献，并对纳入文献进行数据提取和质量评价，使用Stata17.0软件进行Meta分析。结果??最终纳入62篇横断面研究，总样本量为82455例。Meta分析结果显示，我国40~65岁女性人群围绝经期综合征发生率为61.0%。亚组分析结果显示，40~45岁、>45~50岁、>50~55岁、>55~60岁、>60岁女性围绝经期综合征发生率分别为42.6%、53.8%、64.6%、59.7%、56.1%；月经状态为正常、紊乱、绝经的40~65岁女性围绝经期综合征发生率分别为43.6%、56.9%、61.3%；患慢性病、未患慢性病的40~65岁女性围绝经期综合征发生率分别为为85.9%、68.3%；西南地区40~65岁女性围绝经期综合征发生率最高为71.3%，华北、华东、华南、西北、东北、华中地区的发生率分别为57.4%、57.9%、48.5%、59.2%、69.5%、68.6%；文化程度为初中及以下、高中或中专、大学及以上的40~65岁女性围绝经期综合征发生率分别为54.1%、55.7%、49.6%。汉族、少数民族40~65岁女性围绝经期综合征发生率分别为62.1%、64.7%。结论??我国40~65岁女性人群围绝经期综合征发生率高，其中>50~55岁、绝经、患慢性病、西南地区、文化程度为高中及以下、少数民族围绝经期综合发生率较高，应重视相关人群围绝经期综合征的预防、筛查和干预工作，为女性老年期健康奠定基础。
Background ?With the rapid development of economy and society in Chinathe living standards and health care awareness have been improved significantlythe average life expectancy of our population is gradually prolongedcausing increasing population of perimenopausal womenthereforethe health management of perimenopausal women has become more important. Perimenopausal syndrome can be seen in women aged 40-65 yearswhich can seriously affect the physical and mental health and quality of life of patients. Objective??To systematically review the incidence of perimenopausal syndrome in Chinese women aged 40-65 years. Methods??PubMedEmbaseWeb of ScienceCNKIWanfang DataCBM and VIP were searched by computer to collect cross-sectional studies on the occurrence of perimenopausal syndrome in Chinese women aged 40-65 years from inception to February 12023. Two investigators independently screened the literatureextracted data and evaluated the quality of included literature. Meta-analysis was performed using Stata 17.0 software. Results??A total of 62 cross-sectional studies were includedwith a total sample size of 82 455 cases. Meta-analysis showed that the incidence of perimenopausal syndrome in Chinese women aged 40-65 years was 61.0%. The results of subgroup analysis showed that the incidence of perimenopausal syndrome in women aged 40-45 years>45-50 years>50-55 years>55-60 years and >60 years was 42.6%53.8%64.6%59.7% and 56.1%respectively. The incidence of perimenopausal syndrome in women aged 40-65 years with normaldisordered and postmenopausal menstrual status was 43.6%56.9% and 61.3%respectively. The incidence of perimenopausal syndrome in women aged 40-65 years with and without chronic diseases was 85.9% and 68.3%respectively. The incidence of perimenopausal syndrome was highest in women aged 40-65 years in Southwest China at 71.3%and at 57.4%57.9%48.5%59.2%69.5%and 68.6% in NorthEastSouthNorthwestNortheastand Central Chinarespectively. The incidence of perimenopausal syndrome in women aged 40-65 years with education level of junior high school and belowhigh school or technical secondary schooluniversity and above was 54.1 %55.7 % and 49.6 %respectively. The incidence of perimenopausal syndrome in Han Chinese and ethnic minority women aged 40-65 years was 62.1% and 64.7%respectively. Conclusion??The incidence of perimenopausal syndrome is high in women aged 40 to 65 years in China. Among themwomen aged >50-55 yearsmenopausalsuffering from chronic diseasesliving in southwest regionwith education level of high school or belowand ethnic minorities are at high risk of perimenopausal syndrome. We should pay attention to the preventionscreening and intervention of perimenopausal syndrome in relevant population to lay the foundation of elderly health in women.
王晓霞、周紫彤、胡婉琴、熊浪宇、向凤、贾钰、曹学华
10.12114/j.issn.1007-9572.2023.0303
妇产科学医学研究方法
围绝经期更年期综合征围绝经期综合征女性发生率横断面研究Meta 分析
Perimenopauselimacteric syndromePerimenopausal syndromeFemaleIncidenceorsssectional studiesMeta-analysis
王晓霞,周紫彤,胡婉琴,熊浪宇,向凤,贾钰,曹学华.中国40~65岁女性围绝经期综合征发生率的Meta分析[EB/OL].(2023-07-05)[2025-08-17].https://chinaxiv.org/abs/202307.00034.点此复制
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