视黄醇结合蛋白4与2型糖尿病伴高血压的关系

Objective To investigate the serum retinol-binding protein (RBP4) levels change in type 2 diabetes (T2DM) patients with hypertension ,associated with serum retinol-binding protein (RBP4) levels change, and the relationship between with RBP4 and fat metabolism, insulin resistance relationship. Method Selected object 180 cases, including normal control group of 50 patients, 50 Diabetes patients without complications of diabetes,and 80 Diabetic cases associated with hypertension . Detect the fasting serum RBP4, fasting blood glucose (FBG), height, weight, fasting insulin (FINS), glycosylated hemoglobin (HbA1c), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), body mass index (BMI) and homeostasis model assessment insulin resistance index method (HOMA-IR). Analysis of three groups of RBP4 levels, and with the other indicators of relevance. The results of the normal control group, diabetic complications unaccompanied group between the two groups with hypertension and diabetes, RBP4 levels gradually increased; Age, TC, TG, SBP, DBP, in diabetes there are differences between the two sub-groups, with no difference between the normal control group ; diabetes without complications group BMI, HbA1c, HOMA-IR higher than the control group, associated with hypertension and diabetes were no different. HDL-C, LDL-C was no significant difference among the three groups. Multiple linear regression analysis showed no complications in the diabetic group, HbA1c of RBP4 factors; diabetes associated with hypertension, HOMA-IR as RBP4 factor. Conclusion Serum levels of RBP4 is increased in Diabetic associated with hypertension, HbA1c, HOMA-IR may be the factors affecting the RBP4.