含恶唑烷酮结构的Horner试剂的合成及其应用

α,β-unsaturated carbonyl compounds are impoortant in organic synthesis. Among the many methods for the preparation of α,β-unsaturated carbonyl compounds, the Horner-Wadsworth-Emmons (HWE) reaction takes up the leading position with good regioselectivity and stereoselectivity . Based on this, the design and synthesis of novel structures of Horner reagents are of great importance for the synthesis of α,β-unsaturated carbonyl compounds. In this paper, we have designed and synthesized a novel structural Horner reagent containing oxazolidinone , and successfully applied to the preparation of N-H alkylidene-2-oxa-pentalactam precursors, providing a new idea for Horner reagents used in HWE reactions.