超声心动图评价肺动脉高压大鼠的右心结构和功能的动态变化

Objective To evaluate the right heart structure and function of rats with pulmonary arterial hypertension (PAH) dynamically by noninvasive Echocardiography and to explore the indexes reflecting the changes of right heart function at early stages . Methods Forty male SD rats were randomly divided into five groups: the normal contrast group and four experimental groups (i.e., three-, four-, five- and six-week groups), with 8 rats in each group. The rats in the experimental groups were subjected to subcutaneous injection of monocrotaline. Echocardiographic scan were preformed in each group at the specified time. Then pulmonary arterial pressure was measured by right heart catheterization. Echocardiographic data of right heart were analyzed at the EchoPac workstation. Results ①Compared with the normal contrast group, pulmonary arterial pressure of the experimental group was significantly elevated.②Compared with the normal contrast group, right ventricular diameter, right ventricular fractional area change, right ventricular wall thickness, eccentricity index and the ratio of acceleration time and ejection time of the four-week group were significantly changed. Compared with the normal contrast group, tricuspidannular plane systolic excursion, right atrium transverse diameter, right atrium long diameter, right atrium area of the five-week group were significantly changed. Conclusion The remodeling and function of right ventricular with PAH can be early detected and dynamically observed by Echocardiography (i.e., right ventricular diameter, right ventricular fractional area change, right ventricular wall thickness, eccentricity index).