葡萄糖在癌症代谢中的流平衡分析研究

In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate energy needed for the cellular processes, most cancer cells tend to instead rely on aerobic glycolysis. this phenomenon termed "Warburg Effect". Aerobic glycolysis is a ineffective way to generate adenosine 5'-triphosphate (ATP) , however , the advantage it confers to cancer cells remains suspected. Development of high-throughput analysis method results in the explosive growth of omics-data, there needs a sophisticated data analysis model integrating these abundant data to mine bioinformation. In this article, a enhanced flux balance analysis model which integrates tissuse-specific gene-expression and protein-expression data with an existing comprehensive reconstruction of genome-based metabolic network is designed for predicting the tissue-specific metabolic activity features. Thereafter, we utilize our model to explore the reason why and how Warburg Effect occurs, and then we made our guess based on remarkable jobs of others.