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Review of clinical characteristics and laboratory findings of COVID-19 in children-Systematic review and Meta-analysis

Review of clinical characteristics and laboratory findings of COVID-19 in children-Systematic review and Meta-analysis

来源:medRxiv_logomedRxiv
英文摘要

ABSTRACT OBJECTIVETo conduct a systematic review and meta-analysis to assess the prevalence of various clinical symptoms and laboratory findings of COVID-19 in children. METHODSPubMed, MEDLINE, and SCOPUS databases were searched to include studies conducted between January 1, 2020, and July 15, 2020 which reported data about clinical characteristics and laboratory findings in laboratory-confirmed diagnosis of COVID-19 in pediatric patients. Random effects meta-analysis using generalized linear mixed models was used to estimate the pooled prevalence. RESULTSThe most prevalent symptom of COVID-19 in children was 46.17% (95%CI 39.18-53.33%), followed by cough (40.15%, 95%CI 34.56-46.02%). Less common symptoms were found to be dyspnea, vomiting, nasal congestion/rhinorrhea, diarrhea, sore throat/pharyngeal congestion, headache, and fatigue. The prevalence of asymptomatic children was 17.19% (95%CI 11.02-25.82%).The most prevalent laboratory findings in COVID-19 children were elevated Creatinine Kinase (26.86%, 95%CI 16.15-41.19%) and neutropenia (25.76%, 95%CI 13.96-42.58%). These were followed by elevated LDH, thrombocytosis, lymphocytosis, neutrophilia, elevated D Dimer, Elevated CRP, elevated ESR, leukocytosis, elevated AST and leukopenia. There was a low prevalence of elevated ALT and lymphopenia in children with COVID-19. CONCLUSIONS AND RELEVANCEThis study provides estimates of the pooled prevalence of various symptoms and laboratory findings of COVID-19 in the pediatric population.

Kharoud Harmeet Kaur、Asim Rizwana、Chahal Lovepreet、Siegel Lianne、Singh Gagan Deep

Division of Epidemiology, School of Public Health, University of MinnesotaFatima Jinnah Medical UniversitySchool of Health Science Kwantlen Polytechnic UniversityDivision of Biostatistics, School of Public Health, University of MinnesotaDepartment of Internal Medicine, University of Connecticut

10.1101/2020.09.23.20200410

医学研究方法儿科学临床医学

SARS-CoV-2COVID-19PediatricsClinical characteristicsNovel CoronavirusLaboratory Findings

Kharoud Harmeet Kaur,Asim Rizwana,Chahal Lovepreet,Siegel Lianne,Singh Gagan Deep.Review of clinical characteristics and laboratory findings of COVID-19 in children-Systematic review and Meta-analysis[EB/OL].(2025-03-28)[2025-08-18].https://www.medrxiv.org/content/10.1101/2020.09.23.20200410.点此复制

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