猴大脑中动脉闭塞模型不同脑缺血组织脑温变化规律的研究

Objectives: Brain temperature was elevated in acute ischemic stroke, especially in ischemic penumbra (IP). We try to investigate the dynamic evolution of brain temperature in different ischemic regions in monkey models. Methods: The middle cerebral artery occlusion (MCAO) and recanalization model was successfully established in 4 monkeys. Brain temperature of different ischemic regions was measured by Proton magnetic resonance spectroscopy (1H MRS), and then the evolution processes of brain temperature were compared among different ischemic regions. Results: The normal (baseline) brain temperature of monkey brain was 37.16℃. At artery occlusion stage, the mean brain temperature of ischemic tissue was 1.16℃higher than that of the baseline, however, this increase is region-dependent with 1.72℃ in IP, 1.08℃ in infarct core and 0.62℃ in oligemia region. After recanalization, the brain temperature of infarct core showed a pattern of an initially decrease accompanied by a following increase. However, the brain temperature of IP and oligemia region showed a monotonously and slowly decreased pattern. Conclusion: The infarct core and IP have different evolution patterns of brain temperature, which suggests that in vivo measurement of brain temperature could be help to identify whether ischemic tissue is survival.