碘充足地区新生儿甲状腺功能的研究

Objective To understand the iodine status of pregnant women and thyroid function of neonate in an iodine-sufficient area. Methods 174 pregnant women in the third trimester were chosen from Tianjin central gynecological and obstetrical hospital. Then the llimosis morning-urinary of pregnant women and neonates cord blood were collected. The urinary iodine level was examined by Arsenic-cerium catalytic contact. The levels of free triiodothyronine (FT3), free thyroxine (FT4) and sensitive thyroid-stimulating hormone (sTSH) in serum were measured by chemiluminescence. Results ①Urinary iodine median of 174 pregnant women was 217.06μg/L. Most subjects (63.2%) were adequate for iodine nutrition, but some of them were in status of iodine deficiency (27.6%) and iodine excess (9.2%) respectively. ②The average level of FT3, FT4 and sTSH is (2.31±0.28) pmol/L, (16.50±1.35) pmol/L and 4.71(3.96~6.04) μIU/ml Roman)respectively. Neonates with sTSH>5μIU/ml is 41.3%, which was higher than international standard. ③There were no correlations between urinary iodine of pregnant women and FT3, FT4 and sTSH levels of neonate (P>0.05); No staristic significance were found in neonates' FT3, FT4 level with their mothers in different iodine nutrition status,TSH level of the neonates with their mothers in iodine sufficient status were higher than those with their mothers in iodine more than adequate requirements status. ④The level of sTSH of baby boys was higher than baby girls, and baby boys' sTSH tended to higher value distribution. sTSH level of neonates produced by transvaginal was higher than that produced by cesarean section. Conclusion The whole iodine status of pregnant women in this area was adequate, but there were still some iodine deficiency and iodine excess individuals. Neonates whose mothers intook insufficient iodine were more likely to have hypothyroidism and subclinical hypothyroidism. Gender and way of parturition may affect the level of sTSH of neonates.